Preferred Label : Cytokine TWEAK;
MeSH definition : A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily
that is highly expressed in a variety of tissues including heart, pancreas, brain,
and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer
of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation
of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as
well as expression of cytokines involved in INFLAMMATION.;
MeSH synonym : TWEAK, Cytokine; TNF-Related Weak Inducer of Apoptosis; TNF Related Weak Inducer of Apoptosis; TWEAK Cytokine; Cytokine, TWEAK; Tumor Necrosis Factor Ligand Superfamily Member 12; Apo3 Ligand; Ligand, Apo3;
Origin ID : D000074049;
UMLS CUI : C4318640;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- Semantic type(s)
A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily
that is highly expressed in a variety of tissues including heart, pancreas, brain,
and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer
of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation
of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as
well as expression of cytokines involved in INFLAMMATION.
