" /> Cytokine TWEAK - CISMeF





Preferred Label : Cytokine TWEAK;

MeSH definition : A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.;

MeSH synonym : TWEAK, Cytokine; TNF-Related Weak Inducer of Apoptosis; TNF Related Weak Inducer of Apoptosis; TWEAK Cytokine; Cytokine, TWEAK; Tumor Necrosis Factor Ligand Superfamily Member 12; Apo3 Ligand; Ligand, Apo3;

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A proteolytically-cleaved membrane glycoprotein and member of the TNF superfamily that is highly expressed in a variety of tissues including heart, pancreas, brain, and peripheral blood lymphocytes. The secreted extracellular form is a weak inducer of APOPTOSIS for some cell types and a ligand for the FN14 RECEPTOR. It mediates activation of NF-KAPPA-B and promotes ANGIOGENESIS and proliferation of ENDOTHELIAL CELLS, as well as expression of cytokines involved in INFLAMMATION.

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27/07/2025


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