Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 10A;
NCIt synonyms : Cytotoxic TRAIL Receptor; TNFRSF10A; TNF-Related Apoptosis Inducing Ligand Receptor 1; Death Receptor 4; TRAIL Receptor-1; CD261 Antigen; TRAILR-1; TNF-Related Apoptosis-Inducing Ligand Receptor 1;
NCIt related terms : TRAIL receptor 1; TRAIL-R1;
NCIt definition : Tumor necrosis factor receptor superfamily member 10A (468 aa, 50 kDa) is encoded
by the human TNFRSF10A gene. This protein plays a role in the activation of caspase-dependent
apoptosis.;
Alternative definition : NCI-GLOSS: A protein on the surface of certain cells that binds another protein called
TRAIL, which may kill some cancer cells. An increase in the amount or activity of
death receptor 4 on cancer cells may kill more cells.;
NCIt note : A member of the TNF family. TRAIL Receptor 1 (DR4) contains two cysteine-rich pseudorepeats
resembling regions in TNFR1, DR3, and FAS, a transmembrane domain, and an intracellular
death domain. Unlike FAS, TNFR1, and DR3, DR4 does not use FADD to transmit the death
signal, suggesting the use of a distinct signaling machinery.;
Codes from synonyms : CDR0000641145; CDR0000641143; CDR0000641147; CDR0000641146;
Origin ID : C18174;
UMLS CUI : C1504635;
OMIM relation
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- gene_encodes_gene_product
- gene_product_has_associated_anatomy
- gene_product_has_biochemical_function
- gene_product_has_chemical_classification
- gene_product_has_structural_domain_or_motif
- gene_product_is_element_in_pathway
- gene_product_plays_role_in_biological_process
- is_target
