Tumor Necrosis Factor Receptor Superfamily Member 10A

Preferred Label : Tumor Necrosis Factor Receptor Superfamily Member 10A;

NCIt synonyms : Cytotoxic TRAIL Receptor; TNFRSF10A; TNF-Related Apoptosis Inducing Ligand Receptor 1; Death Receptor 4; TRAIL Receptor-1; CD261 Antigen; TRAILR-1; TNF-Related Apoptosis-Inducing Ligand Receptor 1;

NCIt related terms : TRAIL receptor 1; TRAIL-R1;

NCIt definition : Tumor necrosis factor receptor superfamily member 10A (468 aa, 50 kDa) is encoded by the human TNFRSF10A gene. This protein plays a role in the activation of caspase-dependent apoptosis.;

Alternative definition : NCI-GLOSS: A protein on the surface of certain cells that binds another protein called TRAIL, which may kill some cancer cells. An increase in the amount or activity of death receptor 4 on cancer cells may kill more cells.;

NCIt note : A member of the TNF family. TRAIL Receptor 1 (DR4) contains two cysteine-rich pseudorepeats resembling regions in TNFR1, DR3, and FAS, a transmembrane domain, and an intracellular death domain. Unlike FAS, TNFR1, and DR3, DR4 does not use FADD to transmit the death signal, suggesting the use of a distinct signaling machinery.;

Codes from synonyms : CDR0000641145; CDR0000641143; CDR0000641147; CDR0000641146;

Details

Origin ID

C18174;

UMLS CUI

C1504635;

OMIM relation
- Tumor necrosis factor receptor superfamily, member 10a [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- TNFRSF10A protein, human [MeSH Supplementary Concept]
- TNFRSF10A protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
- TNF Receptor Family Gene [NCIt concept]
- TNFRSF10A Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Regulator [NCIt concept]
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Cell Surface Receptor [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Death Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]
is_target
- Dulanermin [NCIt concept]
- Eftozanermin Alfa [NCIt concept]
- Mapatumumab [NCIt concept]
- Recombinant Adenovirus 5 Encoding Tumor Necrosis Factor-related Apoptosis-Inducing Ligand [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients