Dulanermin - CISMeF

Preferred Label : Dulanermin;

NCIt synonyms : APO2L/TRAIL; 114-281-protein TRAIL; rTRAIL; Therapeutic TNF-Related Apoptosis-Inducing Ligand;

NCIt definition : A recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types.;

UNII : L65E7T81M5;

CAS number : 867153-61-5;

Molecule name : RG3639; AMG 951;

Chemical formula : C871H1329N243O260S4;

Details

Origin ID

C1685;

UMLS CUI

C1522480;

Automatic exact mappings (from CISMeF team)
- TNFSF10 protein, human [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- dulanermin [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- dulanermin [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 10A [NCIt concept]
- Tumor Necrosis Factor Receptor Superfamily Member 10B [NCIt concept]

Keyword's position in hierarchy(ies) :

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