" /> Dulanermin - CISMeF





Preferred Label : Dulanermin;

NCIt synonyms : APO2L/TRAIL; 114-281-protein TRAIL; rTRAIL; Therapeutic TNF-Related Apoptosis-Inducing Ligand;

NCIt definition : A recombinant human soluble protein corresponding to amino acids 114-281 of the Apo2 ligand/tumor necrosis factor-related apoptosis-inducing ligand (RhApo2L/TRAIL) with potential antineoplastic activity. Dulanermin binds to and activates TRAIL receptors 1 and 2 (TRAIL-R1/R2), which may activate caspases and induce p53-independent apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors TRAIL-R1 and -R2, also known as DR4 (death receptor 4) and DR5 (death receptor 5), are members of the TNF receptor family and are overexpressed by a variety of cancer cell types.;

UNII : L65E7T81M5;

CAS number : 867153-61-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 867153-61-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : RG3639; AMG 951;

Chemical formula : C871H1329N243O260S4;

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15/05/2024


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