NCIt definition : A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing
ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities.
TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab
selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis
and reducing tumor growth.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It
binds to a protein called TRAIL R1 on the surface of some tumor cells. This may kill
the tumor cells. Anti-TRAIL R1-mAb is a type of monoclonal antibody.;
UNII : WZ1025JPGR;
CAS number : 658052-09-6;
Molecule name : HGS-ETR1;
Codes from synonyms : CDR0000641131; CDR0000643596; 320;