Mapatumumab - CISMeF

Preferred Label : Mapatumumab;

NCIt synonyms : Anti-TRAIL R1-mAb; TRM-1 mAb;

NCIt related terms : HGS-ETR1;

NCIt definition : A fully human agonistic monoclonal antibody to tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) with apoptosis promoting and potential antitumor activities. TRAIL-R1 is a cell surface receptor expressed on many malignant cell types. Mapatumumab selectively binds to and activates the TRAIL cell receptor, thereby inducing apoptosis and reducing tumor growth.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It binds to a protein called TRAIL R1 on the surface of some tumor cells. This may kill the tumor cells. Anti-TRAIL R1-mAb is a type of monoclonal antibody.;

UNII : WZ1025JPGR;

CAS number : 658052-09-6;

Molecule name : HGS-ETR1;

Codes from synonyms : CDR0000641131; CDR0000643596; 320;

Details

Origin ID

C61502;

UMLS CUI

C1665688;

Currated CISMeF NLP mapping
- mapatumumab [MeSH concept]
- mapatumumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- mapatumumab [MeSH concept]
- mapatumumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor Necrosis Factor Receptor Superfamily Member 10A [NCIt concept]

Keyword's position in hierarchy(ies) :

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