Preferred Label : Eftozanermin Alfa;
NCIt synonyms : Hexavalent TRAIL Receptor Agonist ABBV-621; TRAIL-Fc Protein ABBV-621; HERA Ligand ABBV-621; TRAIL-receptor Agonist Fusion Protein ABBV-621; TRAIL Receptor Agonist ABBV-621;
NCIt definition : A fusion protein composed of a tumor necrosis factor (TNF)-related apoptosis-inducing
ligand (TRAIL) receptor agonist consisting of six receptor binding domains (RBDs)
of TRAIL fused to the Fc-domain of a human immunoglobulin G1 (IgG1) antibody, with
potential pro-apoptotic and antineoplastic activities. Upon administration of eftozanermin
alfa, this fusion protein binds to TRAIL-receptors, pro-apoptotic death receptors
(DRs) TRAIL-R1 (death receptor 4; DR4) and TRAIL-R2 (death receptor 5; DR5), expressed
on tumor cells, thereby inducing tumor cell apoptosis. ABBV-621 is designed to maximize
receptor clustering for optimal efficacy. TRAIL, a member of the TNF superfamily of
cytokines, plays a key role in the induction of apoptosis through TRAIL-mediated death
receptor pathways.;
UNII : Q1K9TTP1WS;
CAS number : 1820660-69-2;
Molecule name : APG880; ABBV-621; ABBV 621;
NCI Metathesaurus CUI : CL544836;
Origin ID : C146854;
UMLS CUI : C5418236;
Semantic type(s)
- concept_is_in_subset
- has_target
