Preferred Label : Recombinant Adenovirus 5 Encoding Tumor Necrosis Factor-related Apoptosis-Inducing
Ligand;
NCIt synonyms : Ad5-TNFSF10; Ad5-TRAIL;
NCIt definition : An adenovirus type 5 (Ad5) encoding human tumor necrosis factor-related apoptosis-inducing
ligand (TRAIL), with potential apoptosis-inducing and antineoplastic activities. Upon
administration of recombinant Ad5 encoding TRAIL, the adenovirus selectively infects
tumor cells and expresses TRAIL. The virally expressed TRAIL binds to and activates
its receptors TRAIL receptor-1 (TRAIL-R1, death receptor 4, DR4) and TRAIL receptor-2
(TRAIL-R2, death receptor 5, DR5), which subsequently activate caspases and induce
apoptosis in TRAIL-R1/R2-expressing tumor cells. The pro-apoptotic cell surface receptors
TRAIL-R1 and -R2, members of the TNF receptor family, are overexpressed by a variety
of cancer cell types.;
NCI Metathesaurus CUI : CL446610;
Origin ID : C116879;
UMLS CUI : C3897767;
Semantic type(s)
- concept_is_in_subset
- has_target
