NCIt definition : Tumor necrosis factor ligand superfamily member 10 (281 aa, 33 kDa) is encoded by
the human TNFSF10 gene. This protein plays a role in the induction of apoptosis.;
Alternative definition : NCI-GLOSS: A cell protein that can attach to certain molecules in some cancer cells
and may kill the cells. Apo-2L is being studied in the treatment of cancer.;
NCIt note : Tumor necrosis factor ligand superfamily member 10 binds to TNFRSF10A/TRAILR1 or TNFRSF10B/TRAILR2
to induce apoptosis; while binding to one of the decoy receptors, TNFRSF10C/TRAILR3,
TNFRSF10D/TRAILR4 or TNFRSF11B/OPG, does not induce apoptosis. (UniProt); Tumor necrosis factor ligand superfamily member 10 is a homotrimeric type II membrane
protein that rapidly induces oligomerization of the intracellular death domains of
its receptors and induces apoptosis in a variety of cells.;
Codes from synonyms : CDR0000641163; CDR0000641162; CDR0000641161; CDR0000641164;