Tumor Necrosis Factor Ligand Superfamily Member 10

Preferred Label : Tumor Necrosis Factor Ligand Superfamily Member 10;

NCIt synonyms : TRAIL; TRAIL Protein; TNFSF10; TNF-Related Apoptosis Inducing Ligand TRAIL; Apo-2 Ligand; Tumor Necrosis Factor Ligand Superfamily, Member 10; APO2L; TNFSF10 Protein; APO2 Ligand; TL2; TNF-Related Apoptosis Inducing Ligand; CD253 Antigen; CD253; Chemokine Tumor Necrosis Factor Ligand Superfamily Member 10; Protein TRAIL;

NCIt related terms : TNF-related apoptosis-inducing ligand; tumor necrosis factor-related apoptosis-inducing ligand; Apo-2L;

NCIt definition : Tumor necrosis factor ligand superfamily member 10 (281 aa, 33 kDa) is encoded by the human TNFSF10 gene. This protein plays a role in the induction of apoptosis.;

Alternative definition : NCI-GLOSS: A cell protein that can attach to certain molecules in some cancer cells and may kill the cells. Apo-2L is being studied in the treatment of cancer.;

NCIt note : Tumor necrosis factor ligand superfamily member 10 binds to TNFRSF10A/TRAILR1 or TNFRSF10B/TRAILR2 to induce apoptosis; while binding to one of the decoy receptors, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 or TNFRSF11B/OPG, does not induce apoptosis. (UniProt); Tumor necrosis factor ligand superfamily member 10 is a homotrimeric type II membrane protein that rapidly induces oligomerization of the intracellular death domains of its receptors and induces apoptosis in a variety of cells.;

UNII : 88N2PCJ6LG;

Codes from synonyms : CDR0000641163; CDR0000641162; CDR0000641161; CDR0000641164;

Details

Origin ID

C20533;

UMLS CUI

C1143949;

OMIM relation
- Tumor necrosis factor ligand superfamily, member 10 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TNFSF10 protein, human [MeSH concept]
- TNFSF10 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- TNFSF10 Gene [NCIt concept]
- Tumor Necrosis Factor Family Gene [NCIt concept]
gene_product_expressed_in_tissue
- Lung [NCIt concept]
- Prostate Gland [NCIt concept]
- Spleen [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Apoptosis Promoter [NCIt concept]
- Apoptosis Regulator [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Apoptosis Pathway [NCIt concept]
- Caspase Cascade in Apoptosis [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- DR3 and DR4/5 Mediated Apoptosis Pathway [NCIt concept]
- FOXO Transcription Factor Family Signaling Pathway [NCIt concept]
- Natural Killer Cell-Mediated Cytotoxicity Pathway [NCIt concept]
- TRAIL Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Cell Death Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Tumor Necrosis Factor Receptor Binding [NCIt concept]
- Tumor Necrosis Factor Signaling Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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