Serine/Threonine-Protein Kinase STK11

Preferred Label : Serine/Threonine-Protein Kinase STK11;

NCIt synonyms : LKB1; STK11/LKB1 Protein; STK11; Renal Carcinoma Antigen NY-REN-19; hLKB1; Serine/Threonine Protein Kinase 11; Serine/Threonine-Protein Kinase LKB1; Polarization-Related Protein LKB1; EC 2.7.11.1; Serine-Threonine Protein Kinase-11; Serine/Threonine Protein Kinase STK11; Liver Kinase B1;

NCIt definition : Serine/threonine-protein kinase STK11 (433 aa, 49 kDa) is encoded by the human STK11 gene. This protein plays a role in signal transduction and apoptosis.;

NCIt note : LKB1 physically associates with p53 and regulates specific p53-dependent apoptosis pathways. LKB1 protein translocates to mitochondria during apoptosis. (OMIM);

Details

Origin ID

C18183;

UMLS CUI

C1431123;

OMIM relation
- Serine/threonine protein kinase 11 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- STK11 protein, human [MeSH concept]
- STK11 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- STK11 Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- Kinase [NCIt concept]
gene_product_has_gene_product_variant
- STK11 Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- LKB1 Signaling Pathway [NCIt concept]
- mTOR Signaling Pathway KEGG [NCIt concept]
gene_product_malfunction_associated_with_disease
- Peutz-Jeghers Syndrome [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
- Tumor Suppression [NCIt concept]

Keyword's position in hierarchy(ies) :

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