Leptin Receptor

Preferred Label : Leptin Receptor;

NCIt synonyms : HuB219; OB-R; LEP-R; LEPR Protein; LEPR; OB Receptor; CD295 Antigen;

NCIt definition : Leptin receptor (1165 aa, 132 kDa) is encoded by the human LEPR gene. This protein plays a role in hormone binding, lipid metabolism, and lymphopoiesis.;

NCIt note : Leptin receptor is a type I membrane protein contains 3 fibronectin III-like domains and is tyrosine phosphorylated; the cytoplasmic domain appears essential for signal transduction.;

Details

Origin ID

C26349;

UMLS CUI

C1144168;

Currated CISMeF NLP mapping
- receptors, leptin [MeSH Descriptor]
- receptors, leptin [MeSH concept]
OMIM relation
- Leptin receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- LEPR protein, human [MeSH concept]
- LEPR protein, human [MeSH Supplementary Concept]
- receptors, leptin [MeSH Descriptor]
- receptors, leptin [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- LEPR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Choroid Plexus [NCIt concept]
- Heart [NCIt concept]
- Hematopoietic Tissue [NCIt concept]
- Hypothalamus [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Lung [NCIt concept]
- Ovary [NCIt concept]
- Prostate Gland [NCIt concept]
- Small Intestine [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Protein Hormone Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Cytoplasmic Domain [NCIt concept]
- Extracellular Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Insulin Resistance Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
gene_product_malfunction_associated_with_disease
- Diabetes Mellitus [NCIt concept]
- Obesity [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukopoiesis [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Metabolic Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients