Pro-Opiomelanocortin

Preferred Label : Pro-Opiomelanocortin;

NCIt synonyms : Proopiomelanocortin Preproprotein; Opiomelanocortin Prepropeptide; POMC; Proopiomelanocortin; Corticotropin-Lipotropin;

NCIt definition : Pro-opiomelanocortin (267 aa, 29 kDa) is encoded by the human POMC gene. This protein plays a role in peptide hormone-dependent signaling.;

NCIt note : Pro-opiomelanocortin is cleaved into several biologically active peptides including: NPP, melanotropin gamma (Gamma-MSH), corticotropin (adrenocorticotropic hormone; ACTH), melanotropin alpha (Alpha-MSH), corticotropin-like intermediary peptide (CLIP), lipotropin beta (Beta-LPH), lipotropin gamma (Gamma-LPH), melanotropin beta (Beta-MSH), beta-endorphin and Met-enkephalin. (UniProt);

Details

Origin ID

C114796;

UMLS CUI

C3889630;

Currated CISMeF NLP mapping
- Pro-Opiomelanocortin [MeSH concept]
- Pro-opiomelanocortin (substance) [SNOMED CT concept]
- pro-opiomelanocortin [SNOMED Notion]
- pro-opiomelanocortin [MeSH Descriptor]
OMIM relation
- Proopiomelanocortin [OMIM gene]
See also inter- (CISMeF)
- Proopiomelanocortin [OMIM gene]
- proopiomelanocortin [ORDO Gene]
- proopiomelanocortin [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Hormone [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- POMC Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_is_element_in_pathway
- Adipocytokine Signaling Pathway [NCIt concept]
- Glucocorticoid Receptor Regulatory Network [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Syndecan-3-Mediated Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Appetite [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Stress Response Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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