" /> STK11 wt Allele - CISMeF





Preferred Label : STK11 wt Allele;

NCIt synonyms : PJS; LKB1/STK11 Gene; Serine/Threonine Kinase 11 wt Allele; LKB1; Serine/Threonine Kinase 11 (Peutz-Jeghers Syndrome) Gene;

NCIt definition : Human STK11 wild-type allele is located in the vicinity of 19p13.3 and is approximately 23 kb in length. This allele, which encodes serine/threonine-protein kinase STK11 protein, is involved in cell cycle arrest at the G1 checkpoint and regulation of cell polarity. Certain allelic variants of the STK11 gene cause Peutz-Jeghers syndrome, a hereditary disease characterized by predisposition to benign and malignant tumors of many organ systems.;

NCIt note : The STK11 gene is a tumor suppressor gene. Decreased expression of this gene in breast carcinomas is associated with shorter relapse-free survival. Studies in mice have shown that the STK11 gene plays a critical role in glucose production by the liver.;

GenBank Accession Number : NM_000455;

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15/05/2024


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