Preferred Label : Pyrimethamine-Sulfadoxine;
NCIt synonyms : Pyrimethamine Sulfadoxine;
NCIt related terms : Fansidar;
NCIt definition : A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a
competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the
redox cycle for production of tetrahydrofolate, a cofactor that is required for the
synthesis of DNA and proteins. Sulfadoxine competitively antagonizes paraaminobenzoic
acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis.
Sulfadoxine acts synergistically with pyrimethamine. (NCI04);
Drug name : Fansidar;
NSC code : 618943;
Codes from synonyms : NSC0618943;
Origin ID : C1095;
UMLS CUI : C0700599;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
https://www.who.int/fr/publications/i/item/9789240086272
2024
Switzerland
technical report
Treatment Epoch
Dental Base
Therapy Object
sulfadoxine
Baseline
pregnancy, nos
Pregnant
malaria
During Treatment
malaria
Field
Preventive Intervention
In the Field
Knowledge Field
Quartan Malaria
malaria, nos
Plasmodium Measurement
Base of the Prostate
Data Field
Core Device
Treatment Study
Nucleotide
base, nos
preventive treatment, nos
No Treatment for Diabetes
Guide Device
pyrimethamine with sulfadoxine
Vivax Malaria
pyrimethamine
Pyrimethamine-Sulfadoxine
Pregnancy
Biomaterial Treatment
Preventative Therapy Clinical Trial Setting
GDC Treatment Frequency Terminology
Preventive
Treat
On Treatment
fanasil, pyrimethamine drug combination
Core Specimen
source guides
Electronic System Deployment
Treatment
pregnancy
Malaria Pathway
Baseline Epoch
Under No Medication
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