Glycophorin-B - CISMeF

Preferred Label : Glycophorin-B;

NCIt synonyms : CD235b Antigen; Glycophorin B; SS-Active Sialoglycoprotein; GYPB; PAS-3; Sialoglycoprotein Delta; Glycophorin B Blood Group Antigen; CD235b;

NCIt definition : Glycophorin-B (91 aa, 10 kDa) is encoded by the human GYPB gene. This protein is involved in the antigenic determination of the Ss blood group.;

NCIt note : Glycophorins A (GYPA) and B (GYPB) are sialoglycoproteins of the human erythrocyte membrane and bear the antigenic determinants for the M/N and S/s blood groups. GYPA and GYPB share 97% sequence homology with for the first 45 amino acids. In addition to the M or N and S or s antigens, which are common in all populations, about 40 related variant phenotypes have been identified. These variants include Dantu, Sat, He, Mg, all the variants of the Miltenberger complex and several isoforms of Sta, and deletion variants Ena, S-s-U- and Mk. Most variants result from recombinations between GYPA and GYPB. (EntrezGene);

NCI Metathesaurus CUI : CL411308;

Details

Origin ID

C190144;

UMLS CUI

C1438996;

Automatic exact mappings (from CISMeF team)
- glycophorin B (MNS blood group) [HGNC gene]
Currated CISMeF NLP mapping
- Glycophorin B (substance) [SNOMED CT concept]
- glycophorin B [MeSH concept]
OMIM relation
- Glycophorin b [OMIM gene]
See also inter- (CISMeF)
- Glycophorin b [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- GYPB protein, human [MeSH Supplementary Concept]
- GYPB protein, human [MeSH concept]
Validated automatic mappings to NTBT
- Glycophorins [MeSH Descriptor]
gene_encodes_gene_product
- GYPB Gene [NCIt concept]
- Immunoprotein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Erythrocyte [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Glycophorin [NCIt concept]
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Malaria Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune System Process [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients