Hepatocyte Growth Factor

Preferred Label : Hepatocyte Growth Factor;

NCIt synonyms : HGF/SF; HGF; Scatter Factor; Hepatopoietin A; Lung Fibroblast-Derived Mitogen; Fibroblast-Derived Tumor Cytotoxic Factor; SF;

NCIt definition : Hepatocyte growth factor (728 aa, 83 kDa) is encoded by the human HGF gene. This protein is involved in both the modulation of hepatocyte proliferation and growth factor receptor signaling in hepatocytes and many other cell types.;

NCIt note : Hepatocyte growth factor is secreted as a single chain polypeptide, which is cleaved by serine proteases. The cleaved growth factor is a heterodimer comprised of disulfide bonded alpha- and beta-chains. (EntrezGene and UniProt); Hepatocyte growth factor resembles S1 family peptidases. It has 4 kringle domains and an inactive S1 peptidase domain. (UniProt);

Details

Origin ID

C20428;

UMLS CUI

C1447107;

Currated CISMeF NLP mapping
- hepatocyte growth factor [MeSH Descriptor]
- hepatocyte growth factor [MeSH concept]
OMIM relation
- Hepatocyte growth factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HGF protein, human [MeSH concept]
- HGF protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Growth Factor Gene [NCIt concept]
- HGF Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Kringle Domain [NCIt concept]
gene_product_is_element_in_pathway
- Adherens Junction Stabilization Pathway [NCIt concept]
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- FGF Signaling Pathway [NCIt concept]
- Focal Adhesion Pathway [NCIt concept]
- Hepatocyte Growth Factor Receptor Signaling Pathway BioCarta [NCIt concept]
- Malaria Pathway [NCIt concept]
- Melanoma Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
- Syndecan-1-Mediated Signaling Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Cell Proliferation Regulatory Process [NCIt concept]
- Receptor Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
is_target
- Anti-HGF Monoclonal Antibody TAK-701 [NCIt concept]
- Anti-HGF Monoclonal Antibody YYB101 [NCIt concept]
- Ficlatuzumab [NCIt concept]
- Rilotumumab [NCIt concept]
- TSP-1 Mimetic ABT-510 [NCIt concept]
- VEGF/HGF-targeting DARPin MP0250 [NCIt concept]

Keyword's position in hierarchy(ies) :

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