NCIt definition : A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF)
with potential antineoplastic activity. Ficlatuzumab binds to the soluble ligand HGF,
preventing the binding of HGF to its receptor c-Met and activation of the HGF/c-Met
signaling pathway, which may result in cell death in c-Met-expressing tumor cells.
c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types,
plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.;
UNII : 77E89833TG;
CAS number : 1174900-84-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1174900-84-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;