Ficlatuzumab - CISMeF

Preferred Label : Ficlatuzumab;

NCIt synonyms : Anti-HGF Monoclonal Antibody SCH900105;

NCIt definition : A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF) with potential antineoplastic activity. Ficlatuzumab binds to the soluble ligand HGF, preventing the binding of HGF to its receptor c-Met and activation of the HGF/c-Met signaling pathway, which may result in cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion, and metastasis.;

UNII : 77E89833TG;

CAS number : 1174900-84-5;

Molecule name : AV-299; SCH 900105;

Details

Origin ID

C78844;

UMLS CUI

C2703138;

Automatic exact mappings (from CISMeF team)
- ficlatuzumab [MeSH concept]
Currated CISMeF NLP mapping
- ficlatuzumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ficlatuzumab [MeSH concept]
- ficlatuzumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Hepatocyte Growth Factor [NCIt concept]

Keyword's position in hierarchy(ies) :

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