NCIt definition : A fully human IgG2 monoclonal antibody directed against the human hepatocyte growth
factor (HGF) with potential antineoplastic activity. Anti-HGF monoclonal antibody
AMG 102 binds to and neutralizes HGF, preventing the binding of HGF to its receptor
c-Met and so c-Met activation; inhibition of c-Met-mediated signal transduction may
result in the induction of apoptosis in cells expressing c-Met. c-Met (HGF receptor
or HGFR), a receptor tyrosine kinase overexpressed or mutated in a variety of epithelial
cancer cell types, plays a key role in cancer cell growth, survival, angiogenesis,
invasion, and metastasis.;
Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It binds to a protein
called hepatocyte growth factor (HGF), which may cause cancer cells to grow. Blocking
this may cause cancer cells to die. AMG 102 is a type of monoclonal antibody.;
UNII : 51WEW898IJ;
CAS number : 872514-65-3; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 872514-65-3
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G-SRS /a ;
Molecule name : AMG 102;
Codes from synonyms : CDR0000666706; CDR0000666707; 443;