NCIt definition : A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF)
with potential antineoplastic activity. Anti-HGF monoclonal antibody TAK-701 binds
to the soluble ligand HGF, preventing HGF binding to and activation of the HGF receptor
c-Met and so the activation of the c-Met signaling pathway; this may result in the
induction of cell death in c-Met-expressing tumor cells. c-Met, a receptor tyrosine
kinase overexpressed or mutated in a variety of tumor cell types, plays a key role
in cancer cell growth, survival, angiogenesis, invasion, and metastasis.;
Semantic type(s)