NCIt definition : A humanized monoclonal antibody directed against human hepatocyte growth factor (HGF),
with potential antineoplastic activity. Upon administration, umikibart targets and
binds to HGF, preventing the binding of HGF to the HGF receptor c-Met and the activation
of the c-Met signaling pathway. This may result in cell death in c-Met-expressing
tumor cells. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor
cell types, plays a key role in cancer cell growth, survival, angiogenesis, invasion,
and metastasis.;
Semantic type(s)