TSP-1 Mimetic ABT-510

Preferred Label : TSP-1 Mimetic ABT-510;

NCIt synonyms : NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt; L-Prolinamide, N-acetyl-N-methylglycylglycyl-L-valyl-D-alloisoleucyl-L-threonyl-L-norvalyl-L-isoleucyl-L-arginyl-N-ethyl-; TSP-1-mimetic Peptide ABT-510;

NCIt related terms : ABT-510;

NCIt definition : A synthetic peptide that mimics the anti-angiogenic activity of the endogenous protein thrombospondin-1 (TSP-1). ABT-510 inhibits the actions of several pro-angiogenic growth factors important to tumor neovascularization; these pro-angiogenic growth factors include vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF)), hepatocyte growth factor (HGF), and interleukin 8 (IL-8). (NCI04);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is a type of angiogenesis inhibitor.;

UNII : CRR8E37XOB;

InChIKey : RIWLPSIAFBLILR-WVNGMBSFSA-N;

CAS number : 251579-55-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 251579-55-2 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : ABT510;

Codes from synonyms : 50646; CDR0000367468;

Details

Origin ID

C37447;

UMLS CUI

C1704426;

Automatic exact mappings (from CISMeF team)
- NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt [MeSH concept]
- NAc-Sar-Gly-Val-(d-allo-Ile)-Thr-Nva-Ile-Arg-ProNEt [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- ABT-510 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- ABT-510 [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Fibroblast Growth Factor 2 [NCIt concept]
- Hepatocyte Growth Factor [NCIt concept]
- Interleukin-8 [NCIt concept]
- Vascular Endothelial Growth Factor Family [NCIt concept]
is_component_of_chemotherapy_regimen
- ABT-510/Carboplatin/Paclitaxel [NCIt concept]

Keyword's position in hierarchy(ies) :

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