Preferred Label : GYPA wt Allele;
NCIt synonyms : Glycophorin A, GPA Gene; MNS; Glycophorin A (MN Blood Group) Gene; MN; GPA; HGpMiXI; Glycophorin Sta Type C Gene; CD235a; Glycophorin A (Includes MN Blood Group) Gene; Glycophorin MiI Gene; GlycophorinA Gene; PAS-2; Mi.V Glycoprotein (24 AA) Gene; Glycophorin A (MNS Blood Group) wt Allele; HGpMiV; Glycophorin, Alpha Gene; Glycophorin SAT Gene; HGpSta(C); Glycophorin Erik Gene; Glycophorin MiV Gene; GPErik; GPSAT;
NCIt definition : Human GYPA wild-type allele is located within 4q28.2-q31.1 and is approximately 31
kb in length. This allele, which encodes glycophorin A protein, is involved in the
antigenic determination of M/N and S/s blood groups.;
NCIt note : Along with GYPB, GYPA bears the antigenic determinants for the M/N and S/s blood groups.
The N-terminal glycosylated extracellular segment of the protein product contains
the blood group receptors and binds influenza virus. GYPA gene consists of 7 exons
and has 97% sequence homology with GYPB from the 5' UTR to the coding sequence encoding
the first 45 amino acids. In addition to the M or N and S or s antigens, which are
common in all populations, about 40 related variant phenotypes have been identified.
These variants include Dantu, Sat, He, Mg, all the variants of the Miltenberger complex
and several isoforms of Sta, and deletion variants Ena, S-s-U- and Mk. Most variants
result from recombinations between GYPA and GYPB. (EntrezGene);
GenBank Accession Number : NM_002099;
Origin ID : C52348;
UMLS CUI : C1706550;
False automatic mappings
- OMIM relation
- Semantic type(s)
- gene_found_in_organism
- gene_has_physical_location
- gene_in_chromosomal_location
- gene_is_element_in_pathway
- gene_plays_role_in_process
