Interleukin-11 Receptor Subunit Alpha

Preferred Label : Interleukin-11 Receptor Subunit Alpha;

NCIt synonyms : IL11RA; IL-11RA; Interleukin-11 Receptor Alpha Chain; IL-11R Subunit Alpha; IL-11 Receptor Subunit Alpha; IL-11R-Alpha; Interleukin-11 Receptor Alpha; Interleukin 11 Receptor Alpha;

NCIt definition : Interleukin-11 receptor subunit alpha (422 aa, 45 kDa) is encoded by the human IL11RA gene. This protein is involved in both cytokine signaling and skeletal development.;

NCIt note : Interleukin-11 receptor subunit alpha is the alpha subunit of the high-affinity receptor for interleukin-11. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. (LocusLink);

Details

Origin ID

C26271;

UMLS CUI

C1334200;

OMIM relation
- Interleukin 11 receptor, alpha [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- IL11RA protein, human [MeSH Supplementary Concept]
- IL11RA protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- IL11RA Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Immunoglobulin-Like C2-Type Domain [NCIt concept]
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Interleukin Signaling Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Bone Metastasis Targeting Peptide-11 [NCIt concept]

Keyword's position in hierarchy(ies) :

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