T-Cell Surface Glycoprotein CD5

Preferred Label : T-Cell Surface Glycoprotein CD5;

NCIt synonyms : Lymphocyte Antigen T1/Leu-1; CD5 Antigen; Lymphocyte Antigen CD5;

NCIt related terms : CD5;

NCIt definition : T-cell surface glycoprotein CD5 (495 aa, 54 kDa) is encoded by the human CD5 gene. This protein may be involved in regulating the proliferation of T-cells.;

NCIt note : T-cell surface glycoprotein CD5 is a membrane bound glycoprotein expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies that specifically bind to CD5 can enhance T-cell receptor-mediated T-cell activation. This protein can bind to CD72 antigen. (Abbas et al., Cellular and Molecular Immunology, 2d ed, p156);

Details

Origin ID

C73124;

UMLS CUI

C3887683;

OMIM relation
- Lymphocyte antigen cd5 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CD5 [LOINC component]
- CD5 Ag [LOINC component]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
gene_encodes_gene_product
- CD5 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Scavenger Receptor Cysteine-Rich Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Dendritic Cell Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]
- T-Cell Proliferation [NCIt concept]
is_target
- Allogeneic Anti-CD5 CAR T Cells [NCIt concept]
- Allogeneic Anti-CD5-IL-15/IL-15sushi-safety Switch CAR T Cells [NCIt concept]
- Autologous Anti-CD5 CAR Monocytes MT-101 [NCIt concept]
- Autologous CD5-specific CAR-28 zeta CAR T-cells [NCIt concept]

Keyword's position in hierarchy(ies) :

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