Preferred Label : Autologous Anti-CD5 CAR Monocytes MT-101;
NCIt synonyms : mRNA-engineered CD5-CAR-M MT-101; mRNA-engineered CD5-CAR Monocyte MT-101; CD5 ATAK CAR Monocytes MT-101; Autologous Anti-CD5 CAR-M MT-101;
NCIt definition : A preparation of autologous monocytes genetically modified with mRNA technology to
express a chimeric antigen receptor (CAR) specific for CD5, with potential immunomodulating
and antineoplastic activities. Upon administration, the autologous anti-CD5 CAR monocytes
MT-101 specifically recognize and bind to CD5-expressing tumor cells, and expose the
immune system to the CD5 glycoprotein. This may elicit a cytotoxic T-lymphocyte (CTL)
response against CD5-expressing tumor cells. CD5 is a T-cell surface glycoprotein
expressed on the surface of normal T-cells and overexpressed on various B- and T-cell
malignancies.;
Molecule name : MT 101; MT-101;
NCI Metathesaurus CUI : CL1792221;
Origin ID : C187269;
UMLS CUI : C5706388;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
