Preferred Label : Allogeneic Anti-CD5-IL-15/IL-15sushi-safety Switch CAR T Cells;
NCIt synonyms : Allogeneic CD5-IL-15/IL-15sushi-safety Switch CAR T Cells; Allogeneic CD5-IL-15/IL-15sushi-CAR T-cells; Allogeneic CD5-IL-15/IL-15sushi-safety Switch CAR-T Cells; Anti-CD5 CAR T Cells;
NCIt definition : A preparation of allogeneic T-lymphocytes that have been transduced with a lentiviral
vector to express a chimeric antigen receptor (CAR) consisting of a humanized anti-CD5
single chain variable fragment (scFv) domain linked to a interleukin (IL)-15/IL-15sushi
domain and a safety switch, with potential immunostimulating and antineoplastic activities.
Upon administration, the allogeneic anti-CD5-IL-15/IL-15sushi-safety switch CAR T
cells target and bind to CD5-expressing tumor cells, thereby inducing selective cytotoxicity
in CD5-expressing tumor cells. The IL-15/IL-15sushi domain activates and increases
the levels of natural killer (NK) cells and memory CD8 T-cells. The memory T-cells
enhance the secretion of the cytokine interferon-gamma (IFN-g), which further potentiates
the immune response against tumor cells. This may increase tumor cell killing and
decrease tumor cell proliferation. The pro-survival cytokine IL-15 regulates CD8
T and NK cell development, activation and proliferation. The safety switch, composed
of two rituximab (RTX)-binding epitope sites, allows for the selective elimination
of the CAR-T cells through the administration of RTX. CD5, a T-cell associated antigen,
is expressed in many T-cell lymphomas and leukemias.;
NCI Metathesaurus CUI : CL1648073;
Origin ID : C178587;
UMLS CUI : C5555145;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
