Preferred Label : Allogeneic Anti-CD5 CAR-CD28zeta T-lymphocytes;
NCIt synonyms : Allogeneic CD5-CAR-CD28zeta T-cells; Allogeneic Anti-CD5 CAR-CD28zeta T Cells; Allogeneic CD5CAR-CD28zeta-expressing T-lymphocytes; Allogeneic CD5-specific CAR-28 zeta CAR T-cells; Allogeneic CD5-specific CAR-28zeta T-cells; Allogeneic Anti-CD5 CAR-CD28zeta T-cells; Allogeneic Anti-CD33 CAR-T Cells VCAR33;
NCIt definition : A preparation of genetically modified allogeneic T-cells expressing a chimeric antigen
receptor (CAR) directed against cluster of differentiation 5 (CD5) and linked to the
co-stimulatory signaling domains CD28 and the zeta chain of the TCR/CD3 complex (CD3-zeta)
(CD28zeta), with potential immunomodulating and antineoplastic activities. Upon administration,
the allogeneic anti-CD5 CAR-CD28zeta T-lymphocytes target and bind to CD5-expressing
tumor cells, thereby inducing selective cytotoxicity in CD5-expressing tumor cells.
CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells and
overexpressed on various B- and T-cell malignancies.;
Origin ID : C209977;
concept_is_in_subset
- has_target
