" /> Autologous CD5-specific CAR-28 zeta CAR T-cells - CISMeF





Preferred Label : Autologous CD5-specific CAR-28 zeta CAR T-cells;

NCIt synonyms : CD5.CAR/28zeta CAR T Cells; Autologous CD5.CAR/28zeta CAR T Cells; Autologous CD5-specific CAR-28 zeta CAR T-lymphocytes;

NCIt definition : Autologous T-lymphocytes transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD5 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR), with potential immunomodulating and antineoplastic activities. Upon transfusion, the autologous CD5-specific CAR-28 zeta CAR T-cells are directed to and induce selective toxicity in CD5-expressing tumor cells. The tumor-associated antigen (TAA) CD5 is a T-cell surface glycoprotein expressed on the surface of normal T-cells, and is overexpressed on various B- and T-cell malignancies; its expression is associated with poor prognosis.;

NCI Metathesaurus CUI : CL551051;

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15/05/2024


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