Aminopeptidase N

Preferred Label : Aminopeptidase N;

NCIt synonyms : Antigen CD13; Microsomal Aminopeptidase; Aminopeptidase M; Alanyl Aminopeptidase; hAPN; Myeloid Plasma Membrane Glycoprotein CD13; EC 3.4.11.2; CD13 Antigen; AP-N; gp150; AP-M; ANPEP;

NCIt related terms : AAP; CD13; alanine aminopeptidase;

NCIt definition : Aminopeptidase N (967 aa, 110 kDa) is encoded by the human ANPEP gene. This protein plays a role in the mediation both of peptide hydrolysis and infection by certain viruses.;

Alternative definition : NCI-GLOSS: An enzyme that is normally found in healthy kidneys. It may be found at high levels in the urine when there are kidney problems. It is used as a biomarker to detect damage to the kidneys caused by drugs and other agents. It may also be used to diagnose certain kidney and liver disorders.;

NCIt note : Aminopeptidase N is a biomarker for kidney damage and acute myeloid leukemia.;

Codes from synonyms : CDR0000367453; CDR0000367452;

Détails

Origin ID

C94661;

UMLS CUI

C3887680;

OMIM relation
- Alanyl aminopeptidase [OMIM gene]
See also inter- (CISMeF)
- CD13 [LOINC component]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCIt COVID-19 Clinical Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
gene_encodes_gene_product
- ANPEP Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Metallopeptidase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_chemical_classification
- Metalloprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Metal Binding Site [NCIt concept]
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_is_biomarker_type
- Metastasis and Aggressiveness Marker [NCIt concept]
gene_product_is_element_in_pathway
- Glutathione Metabolism Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Renin-Angiotensin Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Metal Ion Binding [NCIt concept]
- Proteolysis [NCIt concept]
is_target
- CNGRC Peptide-TNF Alpha Conjugate [NCIt concept]

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