CNGRC Peptide-TNF Alpha Conjugate

Preferred Label : CNGRC Peptide-TNF Alpha Conjugate;

NCIt synonyms : NGR-hTNF; CNGRC Peptide-Tumor Necrosis Factor Alpha Conjugate;

NCIt related terms : NGR-TNF; tumor vasculature-targeted tumor necrosis factor alpha;

NCIt definition : A cytokine-peptide conjugate composed of the cytokine tumor necrosis factor alpha (TNF-alpha) chemically linked to the peptide CNGRC. The peptide moiety CNGRC, a ligand for the membrane-bound metalloprotease CD13, binds to endothelial cells of the angiogenic vasculature that express CD13 (also known as aminopeptidase N); subsequently, the TNF-alpha moiety induces apoptosis in endothelial cells expressing CD13, thereby inhibiting tumor-associated angiogenesis. (NCI05);

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of cancer. It is made by linking tumor necrosis factor (TNF) to a peptide. The peptide binds to tumor blood vessels, and TNF damages them. It is a type of biological response modifier.;

Codes from synonyms : CDR0000413951; CDR0000428262;

Details

Origin ID

C48383;

UMLS CUI

C1143119;

Currated CISMeF NLP mapping
- tumor necrosis factor-alpha, CNGRC fusion protein, human [MeSH Supplementary Concept]
- tumor necrosis factor-alpha, CNGRC fusion protein, human [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- tumor necrosis factor-alpha, CNGRC fusion protein, human [MeSH Supplementary Concept]
- tumor necrosis factor-alpha, CNGRC fusion protein, human [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Aminopeptidase N [NCIt concept]

Keyword's position in hierarchy(ies) :

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