Macrophage Colony-Stimulating Factor 1

Preferred Label : Macrophage Colony-Stimulating Factor 1;

NCIt synonyms : Macrophage Colony Stimulating Factor; CSF1; Colony-Stimulating Factor 1; Colony Stimulating Factor 1; Colony Stimulating Factor-1; MCSF; CSF-1; M-CSF;

NCIt definition : Macrophage colony-stimulating factor 1 (554 aa, 60 kDa) is encoded by the human CSF1 gene. This protein is involved in in the regulation of survival, proliferation and differentiation of mononuclear phagocytes.;

NCIt note : The active forms of macrophage colony-stimulating factor 1 may be produced by proteolytic cleavage; precursors may exist as integral membrane proteins. Isoform 1 may undergo rapid proteolytic cleavage to yield an extracellular growth factor. Isoform 3 may exist as an integral membrane protein that undergoes slow proteolysis at the cell surface to yield a soluble growth factor.;

Details

Origin ID

C20437;

UMLS CUI

C3887672;

Currated CISMeF NLP mapping
- colony-stimulating factor 1 [SNOMED Notion]
- colony-stimulating factor, macrophage [SNOMED Notion]
- macrophage Colony-Stimulating factor [MeSH concept]
- macrophage colony-stimulating factor [MeSH Descriptor]
False automatic mappings
- Colony-stimulating factor, macrophage (substance) [SNOMED CT concept]
OMIM relation
- Colony-stimulating factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- CSF1 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CSF1 Gene [NCIt concept]
- Colony-Stimulating Factor Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
- Hematopoietic Factor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Bone Marrow [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Hematopoiesis Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Inflammatory Response Pathway [NCIt concept]
- Integrin Angiogenesis Pathway [NCIt concept]
- LDL Pathway [NCIt concept]
- Macrophage Differentiation Pathway [NCIt concept]
- Macrophage Stimulating 1 Receptor Signaling Pathway [NCIt concept]
- PTPN1 Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Leukopoiesis [NCIt concept]
is_target
- Anti-CSF1 Monoclonal Antibody PD-0360324 [NCIt concept]
- Axl/Mer/CSF1R Inhibitor Q702 [NCIt concept]
- Lacnotuzumab [NCIt concept]

Keyword's position in hierarchy(ies) :

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