Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha

Preferred Label : Granulocyte-Macrophage Colony-Stimulating Factor Receptor Subunit Alpha;

NCIt synonyms : CSF2RA; GM-CSF Receptor Alpha Subunit; CSF2R; Granulocyte-Macrophage Colony-Stimulating Factor Receptor Alpha Chain; CDw116; CD116 Antigen; CD116; GMR; GMCSFR; Low Affinity Granulocyte-Macrophage Colony Stimulating Factor 2 Receptor Alpha; GM-CSF-R-Alpha; Colony Stimulating Factor-2-Receptor Alpha Chain; Colony Stimulating Factor 2 Receptor Alpha Subunit; Colony Stimulating Factor 2 Receptor Alpha Chain; GMR-Alpha; GMCSFR-Alpha;

NCIt definition : Granulocyte-macrophage colony-stimulating factor receptor subunit alpha (400 aa, 46 kDa) is encoded by the human CSF2RA gene. This protein is involved in the production, differentiation, and activation of both granulocytes and macrophages.;

NCIt note : Granulocyte-macrophage colony-stimulating factor receptor subunit alpha is a type I membrane protein with a box 1 motif for JAK interaction/activation; a WSXWS motif for protein folding, intracellular transport, and receptor dimerization.;

Details

Origin ID

C39272;

UMLS CUI

C1522544;

OMIM relation
- Colony-stimulating factor 2 receptor, alpha [OMIM gene]
- Granulocyte-macrophage colony-stimulating factor receptor, alpha subunit, y-chromosomal [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- CSF2RA protein, human [MeSH Supplementary Concept]
- CSF2RA protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CSF2RA Gene [NCIt concept]
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cell Proliferation [NCIt concept]
- Colony Stimulating Factor Signaling Process [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Immune Cell Activation Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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