Thrombopoietin

Preferred Label : Thrombopoietin;

NCIt synonyms : Megakaryocyte Growth and Development Factor; C-MPL Ligand; THPO; TSF; MPL Ligand; MGDF; Megakaryocyte Colony Stimulating Factor; Megakaryocyte Stimulating Factor; Myeloproliferative Leukemia Virus Oncogene Ligand; Prepro-Thrombopoietin; ML; Megakaryocyte Colony-Stimulating Factor;

NCIt related terms : TPO;

NCIt definition : Thrombopoietin (353 aa, 38 kDa) is encoded by the human THPO gene. This protein is involved in both megakaryocyte differentiation and platelet activation.;

Alternative definition : NCI-GLOSS: A substance made by the body that helps make blood cells, especially platelets. A form of TPO made in the laboratory is called recombinant human TPO and rHu TPO. TPO is being studied as a way to increase the number of platelets in cancer patients receiving chemotherapy.;

Codes from synonyms : CDR0000572239; CDR0000046158;

Details

Origin ID

C20441;

UMLS CUI

C3887665;

OMIM relation
- Thrombopoietin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Colony-Stimulating Factor Gene [NCIt concept]
- Cytokine Gene [NCIt concept]
- Hematopoietic Factor Gene [NCIt concept]
- THPO Gene [NCIt concept]
gene_product_expressed_in_tissue
- Liver [NCIt concept]
gene_product_has_associated_anatomy
- Bone Marrow [NCIt concept]
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Growth Factor [NCIt concept]
- Signaling Protein [NCIt concept]
gene_product_has_chemical_classification
- Glycoprotein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Hematopoietic Cell Lineage Pathway [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Differentiation Process [NCIt concept]
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Megakaryocyte Proliferation [NCIt concept]
- Thrombopoiesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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