MPL wt Allele - CISMeF

Preferred Label : MPL wt Allele;

NCIt synonyms : Myeloproliferative Leukemia Virus Oncogene Gene; C-MPL; MPLV; CD110; TPOR Gene; Thrombopoietin Receptor Gene; TPOR; Myeloproliferative Leukemia Virus, Mouse, Homolog of Gene; THCYT2; RP1-92O14.1; MPL Proto-Oncogene, Thrombopoietin Receptor wt Allele;

NCIt definition : Human MPL wild-type allele is located in the vicinity of 1p34.2 and is approximately 46 kb in length. This allele, which encodes thrombopoietin receptor protein, plays a role in megakaryocytopoiesis, hematopoesis and platelet formation. Defects in the gene cause congenital amegakaryocytic thrombocytopenia.;

GenBank Accession Number : NM_005373;

Details

Origin ID

C51375;

UMLS CUI

C1706151;

OMIM relation
- Mpl protooncogene, thrombopoietin receptor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 1p34 [NCIt concept]
gene_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cell Proliferation [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Megakaryocyte Differentiation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Thrombopoiesis [NCIt concept]

Keyword's position in hierarchy(ies) :

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