Leukemia Inhibitory Factor Receptor

Preferred Label : Leukemia Inhibitory Factor Receptor;

NCIt synonyms : LIF-R; LIFR; CD118 Antigen; LIF Receptor; CD118;

NCIt definition : Leukemia inhibitory factor receptor (1097 aa, 124 kDa) is encoded by the human LIFR gene. This protein is involved in leukemia inhibitory factor binding and ligand-dependent signal transduction.;

NCIt note : Leukemia Inhibitory Factor (LIF), encoded by the LIF gene, is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action is mediated through a high-affinity receptor complex composed of Leukemia Inhibitory Factor Receptor (a low-affinity LIF binding chain) and gp130 (a high-affinity converter subunit). The high-affinity complex also binds oncostatin M, a related cytokine. Both Leukemia Inhibitory Factor Receptor and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.;

Details

Origin ID

C26321;

UMLS CUI

C1506606;

OMIM relation
- Leukemia inhibitory factor receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- LIFR protein, human [MeSH concept]
- LIFR protein, human [MeSH Supplementary Concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- LIFR Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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