leukemia inhibitory factor receptor alpha subunit

Preferred Label : leukemia inhibitory factor receptor alpha subunit;

MeSH definition : A receptor subunit that combines with CYTOKINE RECEPTOR GP130 to form the dual specificity receptor for LEUKEMIA INHIBITORY FACTOR and ONCOSTATIN M. The subunit is also a component of the CILIARY NEUROTROPHIC FACTOR RECEPTOR. Both membrane-bound and secreted isoforms of the receptor subunit exist due to ALTERNATIVE SPLICING of its mRNA. The secreted isoform is believed to act as an inhibitory receptor, while the membrane-bound form is a signaling receptor.;

MeSH synonym : antigen, cd118; antigens, cd118; cd118 antigen; cd118 antigens; lif receptor alpha subunit;

Is substance : O;

Details

Origin ID

D053680;

UMLS CUI

C1721043;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CD118 cells [LOINC component]
- LIF receptor subunit alpha [ORDO Gene]
- LIF receptor subunit alpha [HGNC gene]
- LIFR wt Allele [NCIt concept]
- Leukemia Inhibitory Factor Receptor [NCIt concept]
Record concept(s)
- leukemia inhibitory factor receptor alpha subunit [MeSH concept]
Related MeSH Supplementary Concept(s)
- LIFR protein, human [MeSH Supplementary Concept]
- lifr protein, mouse [MeSH Supplementary Concept]
- lifr protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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