CRLF2 wt Allele

Preferred Label : CRLF2 wt Allele;

NCIt synonyms : CRL2; TSLPR; Thymic Stromal-Derived Lymphopoietin Receptor Gene; Cytokine Receptor-Like Factor 2 Gene; Cytokine Receptor Crl2 Gene; CRLF2Y; Cytokine Receptor Like Factor 2 wt Allele;

NCIt definition : Human CRLF2 wild-type allele is located in the vicinity of Xp22.3 and Yp11.3 and is approximately 17 kb in length. This allele, which encodes cytokine receptor-like factor 2 protein, plays a role in the modulation of cytokine signaling. A chromosomal deletion in the pseudoautosomal region 1 of either chromosome X or Y causing fusion of this gene with the P2RY8 gene and chromosomal translocations t(X;14)(p22;q32)/t(Y;14)(p11;q32) of this gene and the IGH locus are associated with B-cell acute lymphoblastic leukemia.;

GenBank Accession Number : AF142570;

Details

Origin ID

C97431;

UMLS CUI

C3273410;

OMIM relation
- Cytokine receptor-like factor 2 [OMIM gene]
- Cytokine receptor-like factor 2, y-linked [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- Xp22.3 [NCIt concept]
- Yp11.3 [NCIt concept]
gene_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_plays_role_in_process
- Cytokine Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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