Leukemia Inhibitory Factor

Preferred Label : Leukemia Inhibitory Factor;

NCIt synonyms : D-Factor; MLPLI; LIF; Human Interleukin in DA Cells; Melanoma-Derived LPL Inhibitor; Differentiation-Stimulating Factor; Differentiation Stimulating Factor; D Factor; Cholinergic Differentiation Factor; Leukemia-Inhibitory Factor; Hepatocyte-Stimulating Factor III; Differentiation Inhibitory Activity;

NCIt definition : Leukemia inhibitory factor (202 aa, 22 kDa) is encoded by the human LIF gene. This protein plays a role in the positive regulation of neuronal cell differentiation and the induction of hematopoietic differentiation in normal and myeloid leukemia cells.;

Details

Origin ID

C20524;

UMLS CUI

C1453955;

Currated CISMeF NLP mapping
- factor D (liver) [MeSH concept]
- factor D (liver) [MeSH Supplementary Concept]
- leukemia inhibitory factor [MeSH Descriptor]
- leukemia inhibitory factor [MeSH concept]
OMIM relation
- Leukemia-inhibitory factor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- LIF protein, human [MeSH concept]
- LIF protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Gene [NCIt concept]
- LIF Gene [NCIt concept]
gene_product_expressed_in_tissue
- T-Lymphocyte [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_biochemical_function
- Signaling Protein [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- NFAT Pathway [NCIt concept]
- p53 Effector Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Receptor Activation [NCIt concept]
- Cytokine Receptor Binding [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Epithelial Cell Proliferation [NCIt concept]
- Hematopoietic Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
is_target
- Falbikitug [NCIt concept]

Keyword's position in hierarchy(ies) :

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