NCIt definition : A humanized immunoglobulin G1 (IgG1) monoclonal antibody against leukemia inhibitory
factor (LIF), with potential immunomodulating and antineoplastic activities. Upon
intravenous administration, falbikitug binds to LIF and inhibits LIF signaling by
blocking the recruitment of glycoprotein 130 (gp130) to the LIF-LIF receptor (LIFR)-gp130
signaling complex. This inhibits signal transducer and activator of transcription
3 (STAT3) signaling and inhibits tumor cell growth. In addition, the inhibition of
LIF signaling abrogates the immunosuppressive tumor microenvironment (TME) by decreasing
immunosuppressive M2 macrophages and allows for the activation of natural killer (NK)
cells and cytotoxic T-lymphocytes (CTLs) against tumor cells. LIF, a member of the
interleukin-6 (IL-6) family of cytokines, is involved in many physiological and pathological
processes and plays an important role in both creating the TME and promoting the activity
of cancer-initiating cells (CICs). LIF is overexpressed in many tumor cell types and
its expression correlates with poor prognosis.;
UNII : E4JL3K3CI6;
CAS number : 2740565-02-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2740565-02-8
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Semantic type(s)