Cytokine-Inducible SH2-Containing Protein

Preferred Label : Cytokine-Inducible SH2-Containing Protein;

NCIt synonyms : CIS-1; Suppressor of Cytokine Signaling; CIS-1 Protein; CISH; Cytokine-Inducible Inhibitor of Signaling Type 1B; Protein G18; G18; Cytokine Inducible SH2-Containing Protein; CISH Protein; CIS; SOCS;

NCIt definition : Cytokine-inducible SH2-containing protein (258 aa, 29 kDa) is encoded by the human CISH gene. This protein is involved in the modulation of signal transduction.;

NCIt note : Proteasome-mediated degradation of cytokine-inducible SH2-containing protein is involved in the inactivation of the erythropoietin receptor.;

Details

Origin ID

C25979;

UMLS CUI

C1742862;

Currated CISMeF NLP mapping
- Curie (qualifier value) [SNOMED CT concept]
- cytokine inducible SH2-containing protein [MeSH concept]
- cytokine inducible SH2-containing protein [MeSH Supplementary Concept]
OMIM relation
- Cytokine-inducible sh2-containing protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CISH protein, human [MeSH concept]
gene_encodes_gene_product
- CISH Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Suppressor of Cytokine Signaling Family Gene [NCIt concept]
gene_product_expressed_in_tissue
- Epithelial Cell [NCIt concept]
- Kidney [NCIt concept]
- Liver [NCIt concept]
- Lung [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_has_structural_domain_or_motif
- SH2 Domain [NCIt concept]
- SOCS Box Domain [NCIt concept]
gene_product_is_element_in_pathway
- Growth Hormone Signaling Pathway [NCIt concept]
- IL2RB Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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