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Suppressor of Cytokine Signaling Family Gene - CISMeF
Suppressor of Cytokine Signaling Family GeneNCIt concept
Preferred Label : Suppressor of Cytokine Signaling Family Gene;
NCIt synonyms : SOCS Family Gene; SSI Family Gene; STAT-Induced STAT Inhibitor Family Gene; CIS Family Gene; Cytokine-Induced STAT Inhibitor Family Gene;
NCIt definition : Suppressor of Cytokine Signaling (SOCS/SSI) Family Genes encode cytokine-specific-inducible
negative feedback regulators that function downstream of cytokine receptors to attenuate
signal transduction. Suppressor of Cytokine Signaling Proteins contain SH2 and SOCS
BOX domains and are implicated, through SOCS box binding, in ubiquitin-dependent protein
degradation. SOCS proteins interact with multiple tyrosine kinase activated signaling
proteins and inhibit cytokine signal transduction by binding to tyrosine kinase receptors.
SOCS proteins regulate cell growth and survival, placental development, hematopoiesis,
and T-cell allergic responses. (NCI);
Semantic type(s)