Suppressor of Cytokine Signaling Family Protein

Preferred Label : Suppressor of Cytokine Signaling Family Protein;

NCIt synonyms : STAT-Induced STAT Inhibitor Family Protein; SSI Family Protein; SOCS Family Protein; CIS Family Protein; Cytokine-Induced STAT Inhibitor Family Protein; SOCS Protein;

NCIt definition : A family of proteins that function downstream of cytokine receptors to modulate signal transduction. Members of the family contain SH2 and SOCS BOX domains.;

NCIt note : SOCS proteins are implicated in ubiquitin-dependent protein degradation. Members of this family of proteins are involved in the regulation of cell growth and survival, placental development, hematopoiesis, and T-cell response to allergens.;

Details

Origin ID

C25978;

UMLS CUI

C1564682;

Automatic exact mappings (from CISMeF team)
- suppressor of cytokine signaling proteins [MeSH concept]
- suppressor of cytokine signaling proteins [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- suppressor of cytokine signaling proteins [MeSH concept]
- suppressor of cytokine signaling proteins [MeSH Descriptor]
gene_encodes_gene_product
- Signaling Pathway Gene [NCIt concept]
- Suppressor of Cytokine Signaling Family Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Cytokine Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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