Thrombopoietin Receptor

Preferred Label : Thrombopoietin Receptor;

NCIt synonyms : TPOR; c-MPL Protein; MPL; CD110 Antigen; CD110; Proto-Oncogene c-Mpl; Myeloproliferative Leukemia Protein; TPO-R;

NCIt definition : Thrombopoietin receptor (635 aa, 71 kDa) is encoded by the human MPL gene. This protein plays a role in thrombopoietin signaling and the regulation of both megakaryocytopoiesis and platelet formation.;

NCIt note : MPL encodes the Thrombopoietin Receptor, a member of the cytokine receptor superfamily. The mechanism by which TPO activates the TPOR appears similar to that of other hematopoietic cytokines that bind and induce receptor homodimerization. TPO regulates the production of multipotent hematopoietic progenitor cells and platelets. Lymphoid progenitors express IL7R and not MPL, whereas myeloid progenitors express MPL and not IL7R. The receptor for thrombopoietin may also represent a regulatory molecule specific for TPOR-dependent immune responses. TPOR contains two fibronectin type III-like domains and is a type I membrane protein. Two isoforms, MPL-K and MPL-P, are produced by alternative splicing and are co-expressed. (from OMIM 159530, SWISS-PROT P40238, and NCI);

Details

Origin ID

C17695;

UMLS CUI

C0218227;

Currated CISMeF NLP mapping
- receptors, thrombopoietin [MeSH Descriptor]
- receptors, thrombopoietin [MeSH concept]
OMIM relation
- Mpl protooncogene, thrombopoietin receptor [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- MPL protein, human [MeSH concept]
- MPL protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Cytokine Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MPL Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_gene_product_variant
- MPL NP_005364.1:p.W515K [NCIt concept]
- MPL NP_005364.1:p.W515L [NCIt concept]
- MPL Protein Variant [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytokine-Cytokine Receptor Signaling Pathway [NCIt concept]
- Jak-STAT Signaling Pathway [NCIt concept]
- TPO Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Proliferation [NCIt concept]
- Cytokine Signaling [NCIt concept]
- Cytokine Signaling Process [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Megakaryocyte Differentiation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]
- Thrombopoiesis [NCIt concept]
is_target
- Eltrombopag [NCIt concept]
- Eltrombopag Olamine [NCIt concept]
- Romiplostim [NCIt concept]
- TPO Receptor Agonist ONO-7746 [NCIt concept]
- Totrombopag [NCIt concept]

Keyword's position in hierarchy(ies) :

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