Preferred Label : Totrombopag;
NCIt synonyms : TPO Mimetic LGD-4665;
NCIt related terms : Thrombopoietin Receptor Agonist LGD-4665;
NCIt definition : An orally available small molecule agonist of the platelet thrombopoietin (TPO) receptor
(TPOR; MPL), with potential megakaryopoiesis stimulating activity. Upon administration,
totrombopag mimics TPO and binds to TPOR. This stimulates TPOR and leads to the proliferation
and differentiation of megakaryocytes in the bone marrow. This increases the production
of blood platelets and decreases bleeding in thrombocytopenic patients. TPOR is a
cytokine receptor and member of the hematopoietin receptor superfamily.;
UNII : 83D6475CAW;
InChIKey : FBYPLSDUAGEJRK-CYYJNZCTSA-N;
CAS number : 1192571-53-1;
Molecule name : LGD-4665;
NCI Metathesaurus CUI : CL554035;
Origin ID : C152703;
UMLS CUI : C4726897;
Semantic type(s)
- concept_is_in_subset
- has_target
