NCIt definition : An orally active thrombopoietin receptor agonist with megakaryopoiesis stimulating
activity. Eltrombopag binds to and stimulates the platelet thrombopoietin receptor
(TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of
TPO-R leads to the proliferation and differentiation of megakaryocytes, thereby increasing
the production of blood platelets.;
Alternative definition : NCI-GLOSS: The active ingredient in a drug used to treat chronic immune thrombocytopenic
purpura (a condition in which platelets are destroyed by the immune system). It causes
more platelets to be made in the bone marrow. It is also being studied in the treatment
of low platelet counts caused by chemotherapy. It is a type of thrombopoietin receptor
agonist.;