" /> Eltrombopag Olamine - CISMeF





Preferred Label : Eltrombopag Olamine;

NCIt synonyms : Eltrombopag;

NCIt related terms : Promacta;

NCIt definition : The orally active ethanolamine salt of eltrombopag, a small-molecule, nonpeptide thrombopoietin receptor agonist with megakaryopoiesis-stimulating activity. Eltrombopag binds to and stimulates the transmembrane domain of the platelet thrombopoietin receptor (TPO-R or CD110), a member of the hematopoietin receptor superfamily. Activation of TPO-R leads to the proliferation and differentiation of cells in the megakaryocytic lineage and an increase in platelet production.;

Alternative definition : NCI-GLOSS: A drug used to treat chronic immune thrombocytopenic purpura (a condition in which platelets are destroyed by the immune system). It causes more platelets to be made in the bone marrow. It is also being studied in the treatment of low platelet counts caused by chemotherapy. It is a type of thrombopoietin receptor agonist.;

UNII : 4U07F515LG;

InChIKey : PLILLUUXAVKBPY-SBIAVEDLSA-N;

CAS number : 496775-62-3;

Drug name : Promacta;

Molecule name : SB-497115-GR; SB 497115 GR;

Chemical formula : C25H22N4O4.2C2H7NO;

Codes from synonyms : CDR0000628802; CDR0000628803;

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10/05/2025


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