Romiplostim - CISMeF

Preferred Label : Romiplostim;

NCIt synonyms : Amgen Megakaryopoiesis Protein 2; AMG531;

NCIt related terms : Nplate; AMG 531;

NCIt definition : A recombinant protein with megakaryopoiesis stimulating activity. Romiplostim mimics endogenous thrombopoietin (TPO), directly binding to and activating the platelet thrombopoietin receptor (TpoR, Mpl, or CD110 antigen), a cytokine receptor belonging to the hematopoietin receptor superfamily. Activation of TpoR stimulates the proliferation and differentiation of megakaryocytes, resulting in an increase in the production of blood platelets.;

Alternative definition : NCI-GLOSS: A drug used to treat patients with immune thrombocytopenic purpura (ITP) who do not get better with other forms of treatment. In ITP, platelets (cells that cause blood clots to form) are destroyed by the immune system. Romiplostim is being studied as a way to treat low platelet counts caused by chemotherapy. It binds to the thrombopoietin receptor and causes the bone marrow to make more platelets. Romiplostim is also being studied in the treatment of myelodysplastic syndromes (a group of diseases in which the bone marrow does not make enough healthy blood cells). It is a type of thrombopoietin agonist.;

UNII : GN5XU2DXKV;

CAS number : 267639-76-9;

Drug name : Nplate;

Molecule name : AMG 531;

Codes from synonyms : CDR0000616115; CDR0000616114; CDR0000616113; 452;

Origin ID

C52183;

UMLS CUI

C2364481;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing romiplostim (medicinal product) [SNOMED CT concept]
- Romiplostim (substance) [SNOMED CT concept]
- romiplostim [ATC Code]
- romiplostim [MeSH Supplementary Concept]
- romiplostim [MeSH concept]
Validated automatic mappings to BTNT
- romiplostim [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Thrombopoietin Receptor [NCIt concept]

Keyword's position in hierarchy(ies) :

Details

Main resources

You can consult :