Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon

Preferred Label : Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon;

NCIt synonyms : I-Kappa-B Kinase Epsilon; EC 2.7.11.10; IKBKE; I-Kappa-B Kinase-Epsilon; IKK-Related Kinase Epsilon; Inducible I Kappa-B Kinase; IKK-E; IKKepsilon; Inducible IkappaB Kinase; IKK-I; IKK-Epsilon; Inducible I-Kappa-B Kinase;

NCIt definition : Inhibitor of nuclear factor kappa-B kinase subunit epsilon (716 aa, 80 kDa) is encoded by the human IKBKE gene. This protein plays a role in the regulation of both nuclear factor kappa-B signaling and interferon expression.;

NCIt note : Inhibitor of nuclear factor kappa-B kinase subunit epsilon is a noncanonical I-kappa-B kinase that is active as a homodimer.;

Details

Origin ID

C147989;

UMLS CUI

C1565878;

Automatic exact mappings (from CISMeF team)
- I-kappa B kinase [MeSH Descriptor]
- IkappaB kinase activity [GO term]
- IkappaB kinase epsilon [MeSH concept]
- Inhibitor of nuclear factor kappa-b kinase, subunit epsilon [OMIM gene]
OMIM relation
- Inhibitor of nuclear factor kappa-b kinase, subunit epsilon [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- IKBKE protein, human [MeSH Supplementary Concept]
- IKBKE protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- IKBKE Gene [NCIt concept]
- Phosphotransferase Gene [NCIt concept]
- Serine/Threonine Protein Kinase Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
- Transferase Gene [NCIt concept]
gene_product_has_biochemical_function
- I-Kappa-B Kinase [NCIt concept]
- Kinase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Cytosolic DNA-Sensing Pathway [NCIt concept]
- NOD-Like Receptor Signaling Pathway [NCIt concept]
- RIG-I-Like Receptor Signaling Pathway [NCIt concept]
- Toll-Like Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Immune Response Process [NCIt concept]
- Interferon Signaling Process [NCIt concept]
- Phosphorylation Process [NCIt concept]
- Protein Phosphorylation Process [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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