I-Kappa-B Kinase

Preferred Label : I-Kappa-B Kinase;

NCIt synonyms : IkappaB Kinase Complex; Nuclear Factor NF-Kappa-B Inhibitor Kinase; IKK; Nuclear Factor NFKappaB Inhibitor Kinase; IKappaB Kinase; Inhibitor of Nuclear Factor Kappa-B Kinase;

NCIt definition : An enzyme complex that is involved in serine/threonine phosphorylation, inflammation and the regulation of the nuclear factor kappa-light-chain-enhancer of activated B cells protein complex. I-kappa-B kinase is comprised of three proteins, inhibitor of nuclear factor kappa-B kinase subunit alpha, beta and gamma.;

NCIt note : I-kappa-B kinase phosphorylates I-kappa B family proteins, which promotes signaling by NF-kappa-B complexes.;

NCI Metathesaurus CUI : CL439178;

Details

Origin ID

C104199;

UMLS CUI

C0663914;

Automatic exact mappings (from CISMeF team)
- I-kappa B kinase [MeSH Descriptor]
- I-kappa B kinase [MeSH concept]
- IkappaB kinase activity [GO term]
- IkappaB kinase complex [GO term]
- component of inhibitor of nuclear factor kappa B kinase complex [ORDO Gene]
- component of inhibitor of nuclear factor kappa B kinase complex [HGNC gene]
Biochemical function of gene products
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon [NCIt concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- I-kappa B kinase [MeSH concept]
- I-kappa B kinase [MeSH Descriptor]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_product_has_biochemical_function
- Serine/Threonine Protein Kinase [NCIt concept]
gene_product_plays_role_in_biological_process
- Serine/Threonine Phosphorylation [NCIt concept]
- Signal Transduction [NCIt concept]
has_gene_product_element
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- NF-Kappa-B Essential Modulator [NCIt concept]

Keyword's position in hierarchy(ies) :

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