I-kappa B kinase

Preferred Label : I-kappa B kinase;

MeSH definition : A protein serine-threonine kinase that catalyzes the PHOSPHORYLATION of I KAPPA B PROTEINS. This enzyme also activates the transcription factor NF-KAPPA B and is composed of alpha and beta catalytic subunits, which are protein kinases and gamma, a regulatory subunit.;

MeSH synonym : b kinase, i-kappa; kinase, ikappab; nk kappa b activating kinase nak; kinase, i-kappa b; ikappab kinase; nk-kappa b-activating kinase nak; I kappa B kinase;

CISMeF synonym : EC 2.7.1.37;

MeSH hyponym : IkappaB kinase epsilon; IkappaB kinase gamma; IkappaB kinase alpha; IkappaB kinase beta; IKK gamma; NF-kappaB Essential Modifier; Essential Modifier, NF-kappaB; NF kappaB Essential Modifier; Kinase epsilon, IkappaB; IKK epsilon; IKKepsilon; Kinase alpha, IkappaB; IKK 1 Kinase; IKK alpha; Conserved Helix-Loop-Helix Ubiquitous Kinase; Conserved Helix Loop Helix Ubiquitous Kinase; CHUK Kinase; I Kappa B alpha-Associated Protein Kinase; I Kappa B alpha Associated Protein Kinase; IkappaBalpha Kinase; Kinase beta, IkappaB; IKK beta; IKBKB; IKK 2 Kinase;

MeSH Related Number : IkappaB kinase gamma; IkappaB kinase epsilon; IkappaB kinase alpha; IkappaB kinase beta; EC 2.7.11.10;

Registry Number MeSH : EC 2.7.11.10;

Related CAS MeSH : EC 2.7.11.10 (IkappaB kinase gamma); EC 2.7.11.10 (IkappaB kinase epsilon); EC 2.7.11.10 (IkappaB kinase alpha); EC 2.7.11.10 (IkappaB kinase beta);

Wikipedia link : https://en.wikipedia.org/wiki/Conserved helix-loop-helix ubiquitous kinase;

Is substance : O;

UNII : EC 2.7.11.10;

Details

Origin ID

D051550;

UMLS CUI

C0663914;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- CHUK wt Allele [NCIt concept]
- Component of nuclear factor kappa-b kinase complex [OMIM gene]
- I-Kappa-B Kinase [NCIt concept]
- IKBKB Gene [NCIt concept]
- IKBKB wt Allele [NCIt concept]
- IKBKG wt Allele [NCIt concept]
- IkappaB kinase activity [GO term]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Alpha [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Beta [NCIt concept]
- Inhibitor of Nuclear Factor Kappa-B Kinase Subunit Epsilon [NCIt concept]
- Inhibitor of nuclear factor kappa-b kinase, subunit beta [OMIM gene]
- Inhibitor of nuclear factor kappa-b kinase, subunit epsilon [OMIM gene]
- NF-Kappa-B Essential Modulator [NCIt concept]
- component of inhibitor of nuclear factor kappa B kinase complex [ORDO Gene]
- component of inhibitor of nuclear factor kappa B kinase complex [HGNC gene]
- inhibitor of nuclear factor kappa B kinase regulatory subunit gamma [ORDO Gene]
- inhibitor of nuclear factor kappa B kinase subunit beta [ORDO Gene]
Indexing information
- (5-(p-fluorophenyl)-2-ureido)thiophene-3-carboxamide [MeSH Supplementary Concept]
- 17-acetoxyjolkinolide B [MeSH Supplementary Concept]
- 2-(4-((4-amino-2-methylphenyl)diazenyl)phenylsulfonyl)ethanesulfonoperoxoic acid [MeSH Supplementary Concept]
- 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimiazo(4,5-d)pyrrolo(2,3-b)pyridin-7-yl)pyridin-2-yl)methyl)acetamide [MeSH Supplementary Concept]
- IMD-1041 [MeSH Supplementary Concept]
- IkK-16 compound [MeSH Supplementary Concept]
- Ikbkg protein, rat [MeSH Supplementary Concept]
- N-(3-(dimethylamino)propyl)-4-((4-(3-fluoro-4-methoxyphenyl)pyrimidin-2-yl)amino)benzenesulfonamide [MeSH Supplementary Concept]
- N-(4-nitrobenzylidene)-2-naphthohydrazide [MeSH Supplementary Concept]
Record concept(s)
- I-kappa B kinase [MeSH concept]
- IkappaB kinase alpha [MeSH concept]
- IkappaB kinase beta [MeSH concept]
- IkappaB kinase epsilon [MeSH concept]
- IkappaB kinase gamma [MeSH concept]
Related MeSH Supplementary Concept(s)
- CHUK protein, human [MeSH Supplementary Concept]
- IKBKB protein, human [MeSH Supplementary Concept]
- IKBKE protein, human [MeSH Supplementary Concept]
- IKBKG protein, human [MeSH Supplementary Concept]
- IKKbeta protein, Drosophila [MeSH Supplementary Concept]
- IKKepsilon protein, Drosophila [MeSH Supplementary Concept]
- Ikbkb protein, rat [MeSH Supplementary Concept]
- chuk protein, mouse [MeSH Supplementary Concept]
- ikbkb protein, mouse [MeSH Supplementary Concept]
- ikbke protein, mouse [MeSH Supplementary Concept]
- key protein, Drosophila [MeSH Supplementary Concept]
See also
- i-kappa b proteins [MeSH Descriptor]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- I-Kappa-B Kinase [NCIt concept]

Keyword's position in hierarchy(ies) :

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