Preferred Label : Adakitug;
NCIt synonyms : HuMax-IL-8; HuMax-IL8; Anti-IL-8 Monoclonal Antibody BMS-986253;
NCIt definition : A human monoclonal antibody against the pro-inflammatory mediator interleukin-8 (IL-8;
CXCL8), with potential antineoplastic activities. Upon administration, adakitug directly
binds to IL-8, thereby inhibiting the binding of IL-8 to its receptors CXCR1 and CXCR2.
This inhibits activation of IL-8-mediated signaling transduction pathways, which decreases
proliferation of susceptible tumor cells. Also, BMS-986253 effectively blocks binding
of IL-8 to neutrophils and inhibits neutrophil activation and recruitment towards
sites of inflammation, which reduces inflammation. IL-8, a member of the CXC chemokine
family, is upregulated in a variety of cancer cell types and inflammatory diseases;
it plays a key role in tumor cell proliferation, endothelial cell proliferation, and
cancer stem cell (CSC) renewal.;
UNII : N0YWS8X3S9;
CAS number : 2231258-73-2;
Molecule name : BMS-986253; MDX-018; MDX 018; BMS 986253;
NCI Metathesaurus CUI : CL502607;
Origin ID : C124227;
UMLS CUI : C4085974;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
