Preferred Label : MYC-targeting siRNA DCR-MYC;
NCIt definition : A lipid nanoparticle-based formulation consisting of small-interfering RNAs (siRNAs)
directed against the oncogene c-Myc encapsulated in lipids with potential antineoplastic
activity. Upon intravenous administration of MYC-targeting siRNA DCR-MYC, the lipid
formulation promotes the uptake by tumor cells where the siRNAs moieties are subsequently
released. The siRNAs bind to c-Myc mRNAs, which may result in the inhibition of translation
and expression of the c-Myc protein and leads to growth inhibition for tumor cells
that are overexpressing c-Myc. c-Myc, a proto-oncogene overexpressed in a variety
of cancers, is involved in cellular proliferation, differentiation, and apoptosis.;
Molecule name : DCR-M1711; DCR-MYC;
NCI Metathesaurus CUI : CL472639;
Origin ID : C115108;
UMLS CUI : C3896879;
Semantic type(s)
- concept_is_in_subset
- has_target
